A conformationally constrained vasopressin analog with antidiuretic antagonistic activity

See allHide authors and affiliations

Science  26 Oct 1984:
Vol. 226, Issue 4673, pp. 443-445
DOI: 10.1126/science.6541806


Application of information derived from a three-dimensional model of vasopressin bound to its antidiuretic receptor resulted in the design and synthesis of a bicyclic vasopressin analog, [5,8-cyclo(1-beta-mercaptopropionic acid,2-phenylalanine,5-aspartic acid,8-lysine)]vasopressin. The analog acts as an antagonist of the antidiuretic activity of vasopressin.