Growth hormone-releasing factor: direct effects on growth hormone, glucose, and behavior via the brain

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Science  26 Oct 1984:
Vol. 226, Issue 4673, pp. 464-466
DOI: 10.1126/science.6436973


Intracerebroventricular administration of human pancreatic growth hormone-releasing factor caused a dose-dependent inhibition of growth hormone secretion, elevated plasma glucose concentrations, and produced marked behavioral and motor effects. Immunoneutralization with antiserum to somatostatin did not reverse the suppression of growth hormone. These findings suggest that hypothalamic growth hormone-releasing factor may regulate its own neurosecretion through an "ultrashort-loop" negative feedback mechanism and may have important neurotransmitter and neuromodulatory functions in the brain.