Constitutive fragile sites and cancer

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Science  07 Dec 1984:
Vol. 226, Issue 4679, pp. 1199-1204
DOI: 10.1126/science.6239375


Breaks were observed at 51 sites in homologous chromosomes in lymphocytes from ten humans and two great apes when cells were deprived of thymidine. The incidence of breaks was enhanced by caffeine, a substance that inhibits DNA repair in replicating cells. The locations of 20 sites were correlated with breakpoints that have been related to human malignancy.