Reports

Monoclonal idiotope vaccine against Streptococcus pneumoniae infection

Science  14 Dec 1984:
Vol. 226, Issue 4680, pp. 1325-1326
DOI: 10.1126/science.6505692

Abstract

A monoclonal anti-idiotope antibody coupled to a carrier protein was used to immunize BALB/c mice against a lethal Streptococcus pneumoniae infection. Vaccinated mice developed a high titer of antibody to phosphorylcholine, which is known to protect against infection with Streptococcus pneumoniae. Measurement of the median lethal dose of the bacteria indicated that anti-idiotope immunization significantly increased the resistance of BALB/c mice to the bacterial challenge. Antibody to an idiotope can thus be used as an antigen substitute for the induction of protective immunity.

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