Effects of extracellular egg factors on sperm guanylate cyclase

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Science  15 Feb 1985:
Vol. 227, Issue 4688, pp. 768-770
DOI: 10.1126/science.2857502


Extracellular factors from the sea urchin egg induce a change in the electrophoretic mobility of an abundant sperm membrane phosphoprotein. The modified protein was identified as guanylate cyclase. The mobility shift of the cyclase was shown to be associated with a decrease in its enzymatic activity.