Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome

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Science  01 Mar 1985:
Vol. 227, Issue 4690, pp. 1041-1044
DOI: 10.1126/science.2858126


Hemorrhagic fever with renal syndrome (HFRS) comprises a variety of clinically similar diseases of viral etiology that are endemic to and sporadically epidemic throughout the Eurasian continent and Japan. Although HFRS has not been reported in North America, viruses that are antigenically similar to HFRS agents were recently isolated from rodents in the United States. Examination and comparison of eight representative isolates from endemic disease areas and from regions with no known associated HFRS indicate that these viruses represent a new and unique group that constitutes a separate genus in the Bunyaviridae family of animal viruses.