A second nuclear protein is encoded by Epstein-Barr virus in latent infection

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Science  08 Mar 1985:
Vol. 227, Issue 4691, pp. 1238-1240
DOI: 10.1126/science.2983420


A region of the Epstein-Barr virus (EBV) genome that is important in inducing cell proliferation includes a single long open reading frame. Part of this open reading frame has been fused to the lacZ gene and expressed in Escherichia coli. Antisera to the fusion protein identify a protein in the nuclei of latently infected growth-transformed lymphocytes and in Burkitt tumor cells grown in vitro. This nuclear protein is encoded by a different virus-gene than that which encodes the previously described EBV nuclear antigen, EBNA.