Diagnostic ultrasound and sister chromatid exchanges: failure to reproduce positive findings

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Science  15 Mar 1985:
Vol. 227, Issue 4692, pp. 1349-1351
DOI: 10.1126/science.3883487


Human lymphocytes were exposed in vitro to ultrasound from two clinical devices, one of which was previously reported to have increased the frequency of sister chromatid exchanges. The ultrasonic exposures had no significant effect on the frequency of sister chromatid exchanges from three blood donors. Exposure to ultrasound also had no effect on cell cycle progression. A concomitant positive control (mitomycin C) resulted in a significant increase in sister chromatid exchanges.