Evidence for a malarial parasite interaction site on the major transmembrane protein of the human erythrocyte

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Science  05 Apr 1985:
Vol. 228, Issue 4695, pp. 75-77
DOI: 10.1126/science.3883494


Soluble oligosaccharides derived from the surface of human erythrocytes were tested for their ability to competitively inhibit invasion of erythrocytes by Plasmodium falciparum, a malarial parasite. Invasion was most effectively inhibited by erythroglycan, a carbohydrate component of the band 3 transmembrane protein. The lactosamine chains of erythroglycan contributed much of the inhibitory activity. This indication of a primary parasite interaction site on band 3 supports a role for this protein in mediating the radical alterations of the erythrocyte cytoskeleton that accompany invasion.