Genotoxicity of formaldehyde in cultured human bronchial fibroblasts

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Science  05 Apr 1985:
Vol. 228, Issue 4695, pp. 89-91
DOI: 10.1126/science.3975633


Formaldehyde, a common environmental pollutant, inhibits repair of O6-methylguanine and potentiates the mutagenicity of an alkylating agent, N-methyl-N-nitrosourea, in normal human fibroblasts. Because formaldehyde alone also causes mutations in human cells, the compound may cause genotoxicity by a dual mechanism of directly damaging DNA and inhibiting repair of mutagenic and carcinogenic DNA lesions caused by other chemical and physical carcinogens.