Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells

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Science  03 May 1985:
Vol. 228, Issue 4699, pp. 580-582
DOI: 10.1126/science.3983641


The T-cell receptor is formed by two chains, alpha and beta, for which specific clones were recently obtained. In this report the gene for the beta chain of the human T-cell receptor was located on the long arm of chromosome 7, band q35, by means of in situ hybridization. This chromosome region in T cells is unusually prone to develop breaks in vivo, perhaps reflecting instability generated by somatic rearrangement of T-cell receptor genes during normal differentiation in this cell lineage.