Epizootic Carcinoma in the Winter Flounder, Pseudopleuronectes americanus

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Science  03 May 1985:
Vol. 228, Issue 4699, pp. 587-589
DOI: 10.1126/science.228.4699.587


The winter flounder, Pseudopleuronectes americanus, is an esteemed food fish and has sustained an important commercial and recreational fishery for many years in the northeastern United States. Histopathologic examinations of hepatic tissues of winter flounder from Boston Harbor revealed a high prevalence of neoplasms. The lesions, designated as cholangiocarcinomas and hepatocarcinomas, were found in 16 of 200 fish examined and resembled those experimentally induced in rodents by exposure to carcinogens.