Intracellular stimulation of an identified neuron evokes cardioacceleratory peptide release

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Science  24 May 1985:
Vol. 228, Issue 4702, pp. 1013-1015
DOI: 10.1126/science.4001929


The central nervous system of the tobacco hawkmoth, Manduca sexta, is known to contain two cardioacceleratory peptides (CAP's), both of which function in vivo as cardioregulatory neurohormones. Intracellular electrical stimulation of a single abdominal ganglion neuron evokes the release of CAP-like bioactivity. This stimulation-evoked bioactivity is destroyed by prior treatment with protease. The possibility that intracellular stimulation of a CAP-containing neuron synaptically activated additional spiking neurons is eliminated.