A catalytic RNA and its gene from Salmonella typhimurium

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Science  24 May 1985:
Vol. 228, Issue 4702, pp. 999-1002
DOI: 10.1126/science.2408335


The gene for the RNA subunit (M1 RNA) of ribonuclease P from Salmonella typhimurium directs the synthesis of an RNA that can cleave transfer RNA precursor molecules. The mature M1 RNA coded for by Salmonella typhimurium is 375 nucleotides long and has six nucleotide changes in comparison to M1 RNA from Escherichia coli. The regions for promotion and termination of transcription are closely conserved, but adjacent regions of nucleotide sequences show considerable drift.