Reports

Localization of the gene encoding the human interleukin-2 receptor on chromosome 10

Science  28 Jun 1985:
Vol. 228, Issue 4707, pp. 1547-1549
DOI: 10.1126/science.3925551

Abstract

The human interleukin-2 receptor is an inducible growth factor receptor present on the surface of activated T lymphocytes. The receptor is required for a normal T-cell immune response. High-resolution fluorescence-activated chromosome sorting and DNA spot-blot analysis with complementary DNA's for the interleukin-2 receptor indicated that the receptor gene was located on chromosome 9, 10, 11, or 12. In situ hybridization studies showed that the interleukin-2 receptor gene is on the short arm of chromosome 10, p14----15.