The granulocyte-macrophage colony-stimulating factors

Science  05 Jul 1985:
Vol. 229, Issue 4708, pp. 16-22
DOI: 10.1126/science.2990035


The granulocyte-macrophage colony-stimulating factors are well-characterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocyte-macrophages. Widely produced in the body, these regulators probably play an important role in resistance to infections. The proliferation of myeloid leukemia cells remains dependent on stimulation by colony-stimulating factors, although one of them also has the ability to suppress leukemic populations by inducing terminal differentiation.

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