Neurotrophic factors

Science  19 Jul 1985:
Vol. 229, Issue 4710, pp. 238-242
DOI: 10.1126/science.2409599


In addition to nerve growth factor (NGF), many proteins present in soluble tissue extracts and in the extracellular matrix influence the survival and development of cultured neurons. The structure, synthesis, and mechanism of action of NGF as a neurotrophic factor are considered along with the experiments on the new putative trophic molecules.