Reports

Molecular cloning of a gene sequence regulated by nerve growth factor

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Science  26 Jul 1985:
Vol. 229, Issue 4711, pp. 393-395
DOI: 10.1126/science.3839317

Abstract

Nerve growth factor (NGF) is essential for the development and differentiation of sympathetic or sensory neurons. A complementary DNA was cloned that corresponds to a gene sequence induced more than 50-fold in a cultured target cell line of pheochromocytoma cells (PC12 cells) 5 hours after the addition of NGF. The induced messenger RNA encodes a 90,000-dalton polypeptide that may represent one of the primary events in NGF-induced differentiation of neurons.