Regeneration of functional synapses between individual recognizable neurons in the lamprey spinal cord

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Science  23 Aug 1985:
Vol. 229, Issue 4715, pp. 774-776
DOI: 10.1126/science.2992085


In 4- to 5-year-old sea lamprey larvae that had recovered from complete transection of the spinal cord, pairs of giant interneurons on opposite sides of the scar were impaled with microelectrodes. In 4 of 30 pairs, stimulation of the caudal cell elicited a monosynaptic electrochemical excitatory postsynaptic potential in the rostral cell. Fifty percent of such pairs were synaptically linked in control lampreys without transections. These results show regeneration of functional synaptic connections between individual neurons in a vertebrate central nervous system.