Reports

Recombinant vaccinia virus: immunization against multiple pathogens

Science  06 Sep 1985:
Vol. 229, Issue 4717, pp. 981-984
DOI: 10.1126/science.2992092

Abstract

The coding sequences for the hepatitis B virus surface antigen, the herpes simplex virus glycoprotein D, and the influenza virus hemagglutinin were inserted into a single vaccinia virus genome. Rabbits inoculated intravenously or intradermally with this polyvalent vaccinia virus recombinant produced antibodies reactive to all three authentic foreign antigens. In addition, the feasibility of multiple rounds of vaccination with recombinant vaccinia virus was demonstrated.

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