Enzymatic removal of bilirubin from blood: a potential treatment for neonatal jaundice

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Science  01 Nov 1985:
Vol. 230, Issue 4725, pp. 543-545
DOI: 10.1126/science.4048947


Current treatments for severe jaundice can result in major complications. Neonatal jaundice is caused by excessive accumulation of bilirubin in the blood. A small blood filter containing immobilized bilirubin oxidase was developed to reduce serum bilirubin concentrations. When human or rat blood was passed through the enzyme filter, more than 90 percent of the bilirubin was degraded in a single pass. This procedure may have important applications in the clinical treatment of neonatal jaundice.