Direct evidence that endogenous GM1 ganglioside can mediate thymocyte proliferation

See allHide authors and affiliations

Science  13 Dec 1985:
Vol. 230, Issue 4731, pp. 1285-1287
DOI: 10.1126/science.2999979


The B subunit of cholera toxin, which is multivalent and binds exclusively to a specific ganglioside, GM1, was mitogenic for rat thymocytes. When exposed to the B subunit, the cells proliferated, as measured by 3H-labeled thymidine incorporation. Mitogenesis depended on the direct interaction of the B subunit with GM1 on the surface of the cells. This demonstrates that endogenous plasma membrane gangliosides can mediate proliferation in lymphocytes.