Reports

A new class of steroids inhibits angiogenesis in the presence of heparin or a heparin fragment

Science  20 Dec 1985:
Vol. 230, Issue 4732, pp. 1375-1378
DOI: 10.1126/science.2416056

Abstract

Steroids that lack glucocorticoid or mineralocorticoid activity were found to inhibit angiogenesis in the presence of heparin or specific heparin fragments. This newly discovered steroid function appears to be governed by distinct structural configurations of the pregnane nucleus. These compounds are here named angiostatic steroids.

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