Dynamics of lymphocyte-endothelial interactions in vivo

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Science  24 Jan 1986:
Vol. 231, Issue 4736, pp. 402-405
DOI: 10.1126/science.3941903


The dynamics of the attachment of lymphocytes to the endothelium of high endothelial venules in murine Peyer's patches were studied in vivo. Lymphocytes adhered readily to the endothelium lining these vessels, but most of the adhering cells detached within a few seconds. Many lymphocytes, however, experienced multiple collisions with the high endothelial venules, and this substantially increased the efficiency of lymphocyte collection by these vessels.