Mammalian metallothionein is functional in yeast

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Science  21 Feb 1986:
Vol. 231, Issue 4740, pp. 854-856
DOI: 10.1126/science.3080806


Expression of two monkey metallothioneins in yeast leads to complementation of both known functions of the endogenous yeast copperthionein gene, namely copper detoxification and autoregulation of transcription. The metallothionein-like proteins of higher and lower eukaryotes are therefore functionally analogous despite their dissimilar primary sequences.