Reports

Mammalian metallothionein is functional in yeast

Science  21 Feb 1986:
Vol. 231, Issue 4740, pp. 854-856
DOI: 10.1126/science.3080806

Abstract

Expression of two monkey metallothioneins in yeast leads to complementation of both known functions of the endogenous yeast copperthionein gene, namely copper detoxification and autoregulation of transcription. The metallothionein-like proteins of higher and lower eukaryotes are therefore functionally analogous despite their dissimilar primary sequences.

Related Content