Detection of alpha-transducin in retinal rods but not cones

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Science  21 Feb 1986:
Vol. 231, Issue 4740, pp. 856-859
DOI: 10.1126/science.3080807


The distribution in chicken retina of the alpha subunit of transducin, the guanine nucleotide--binding protein that couples light-dependent activation of rhodopsin with activation of guanosine 3',5'-monophosphate phosphodiesterase, was determined with the aid of a specific antiserum. alpha-Transducin was found in rod photoreceptor cells but was not detected in cones. These results show that rods and cones differ with respect to alpha-transducin content and suggest that the processes of phototransduction may differ correspondingly in rods and cones.