Human beta-adrenoceptors: relation of myocardial and lymphocyte beta-adrenoceptor density

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Science  28 Mar 1986:
Vol. 231, Issue 4745, pp. 1584-1585
DOI: 10.1126/science.3006250


In human right atria obtained from 21 patients during open-heart surgery, beta-adrenoceptor density [assessed by iodine-125-labeled (-)-cyanopindolol binding] and responsiveness (positive inotropic responses to isoprenaline) were linearly related to the beta-adrenoceptor density in the corresponding circulating lymphocytes. This direct relation of human myocardial and lymphocyte beta-adrenoceptor alterations, therefore, makes it possible to monitor drug- or disease-induced beta-adrenoceptor changes in tissues not easily accessible in humans.