Research Articles

Molecular genetics of human color vision: the genes encoding blue, green, and red pigments

Science  11 Apr 1986:
Vol. 232, Issue 4747, pp. 193-202
DOI: 10.1126/science.2937147

Abstract

Human color vision is based on three light-sensitive pigments. The isolation and sequencing of genomic and complementary DNA clones that encode the apoproteins of these three pigments are described. The deduced amino acid sequences show 41 +/- 1 percent identity with rhodopsin. The red and green pigments show 96 percent mutual identity but only 43 percent identity with the blue pigment. Green pigment genes vary in number among color-normal individuals and, together with a single red pigment gene, are proposed to reside in a head-to-tail tandem array within the X chromosome.

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