Reports

Potential metal-binding domains in nucleic acid binding proteins

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Science  25 Apr 1986:
Vol. 232, Issue 4749, pp. 485-487
DOI: 10.1126/science.2421409

Abstract

A systematic search for sequences that potentially could form metal-binding domains in proteins has been performed. Five classes of proteins involved in nucleic acid binding or gene regulation were found to contain such sequences. These observations suggest numerous experiments aimed at determining whether metal-binding domains are present in these proteins and, if present, what roles such domains play in the processes of nucleic acid binding and gene regulation.