Time-resolved X-ray diffraction studies of the B in equilibrium D structural transition in the DNA double helix

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Science  11 Jul 1986:
Vol. 233, Issue 4760, pp. 195-197
DOI: 10.1126/science.3726529


Because of the relation between topology and function, there has been much interest in the structural transitions of the various conformations of DNA polymers. The x-ray fiber diffraction analysis system at the Daresbury Synchrotron Radiation Source was used to study the reversible transition between the B and D forms of the synthetic DNA poly[d(A-T)].poly[d(A-T)]. The gradual progression of conformations between these two forms indicates that the DNA double helix does not undergo a change of handedness during this transition.