Articles

Early signals in the mitogenic response

Science  10 Oct 1986:
Vol. 234, Issue 4773, pp. 161-166
DOI: 10.1126/science.3018928

Abstract

Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents acting alone or synergistically induce mitogenesis in cultured fibroblasts. The early signals in the membrane, cytosol, and nucleus promoted by these extracellular factors, together with their mitogenic effectiveness, are integrated in a unified hypothesis for the regulation of fibroblast growth.

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