The trans Golgi network: sorting at the exit site of the Golgi complex

Science  24 Oct 1986:
Vol. 234, Issue 4775, pp. 438-443
DOI: 10.1126/science.2945253


The Golgi complex is a series of membrane compartments through which proteins destined for the plasma membrane, secretory vesicles, and lysosomes move sequentially. A model is proposed whereby these three different classes of proteins are sorted into different vesicles in the last Golgi compartment, the trans Golgi network. This compartment corresponds to a tubular reticulum on the trans side of the Golgi stack, previously called Golgi endoplasmic reticulum lysosomes (GERL).

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