Cultivation of Rhinosporidium seeberi in vitro: interaction with epithelial cells

Science  24 Oct 1986:
Vol. 234, Issue 4775, pp. 474-476
DOI: 10.1126/science.3764422


Rhinosporidium seeberi, a fungus that is associated with polyp-like tumors in animals and man, was successfully cultivated. This organism stimulated proliferation of epithelial cells in vitro, producing polyp-like structures. Spores produced in culture required a period of aging or development, or both, before they were capable of reinitiating the growth cycle.