Construction of a novel oncogene based on synthetic sequences encoding epidermal growth factor

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Science  16 Jan 1987:
Vol. 235, Issue 4786, pp. 321-324
DOI: 10.1126/science.3492043


The autocrine model postulates that constitutive release of a mitogenic growth factor can lead to uncontrolled proliferation and cell transformation. A synthetic polynucleotide encoding epidermal growth factor conferred a tumorigenic phenotype on cells. These cells were transformed through the action of an autocrine circuit having an extracellular component.