Region-specific expression of two mouse homeo box genes

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Science  13 Mar 1987:
Vol. 235, Issue 4794, pp. 1379-1382
DOI: 10.1126/science.2881353


Mammalian homeo box genes have been identified on the basis of sequence homology to Drosophila homeotic and segmentation genes. These studies examine the distribution of transcripts from two mouse homeo box genes, Hox-2.1 and Hox-3.1, throughout the latter third of prenatal development. Transcripts from these genes are regionally localized along the rostro-caudal axis of the developing central nervous system, yielding expression patterns very similar to patterns of Drosophila homeotic gene expression.