Corrections and Clarifications


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Science  03 Apr 1987:
Vol. 236, Issue 4797, pp. 12
DOI: 10.1126/science.236.4797.12-b


In Mark Crawford's article "Genentech sues FDA on growth hormone" (News & Comment, 20 Mar., p. 1454), antibody response that occurs in some patients using Protropin was incorrectly portrayed as the result of the product's 192nd amino acid—a methionyl. While the methionyl may be involved in the antibody responses of a limited number of Protropin users, there is evidence that antibody formation is a result of a number of factors. In particular, the precise details of the manufacturing process appear to be the major factor in determining the antigenicity of growth hormone preparations.