Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system

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Science  25 Sep 1987:
Vol. 237, Issue 4822, pp. 1610-1614
DOI: 10.1126/science.3629259


A complementary DNA clone derived from rat brain messenger RNA has been isolated on the basis of homology to the human thyroid hormone receptor gene. Expression of this complementary DNA produces a high-affinity binding protein for thyroid hormones. Sequence analysis and the mapping of this gene to a distinct human genetic locus indicate the existence of multiple human thyroid hormone receptors. Messenger RNA from this gene is expressed in a tissue-specific fashion with highest levels in the central nervous system.