Time-resolved x-ray diffraction of biological materials

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Science  16 Oct 1987:
Vol. 238, Issue 4825, pp. 305-312
DOI: 10.1126/science.3310232


Instrumental and specimen considerations pertinent to performing time-resolved x-ray diffraction on biological materials are discussed. Existing synchrotron x-ray sources, in conjunction with integrating x-ray detectors, have made millisecond diffraction experiments feasible; exposure times several orders of magnitude shorter than this will be possible with synchrotron sources now on the drawing boards. Experience gained from time-resolved studies together with order-of-magnitude estimates of specimen requirements can be used to determine the instrumental capabilities needed for various time-resolved experiments. Existing instrumental capabilities and methods of dealing with time-resolved specimens are reviewed.