Nerve terminal remodeling visualized in living mice by repeated examination of the same neuron

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Science  20 Nov 1987:
Vol. 238, Issue 4830, pp. 1122-1126
DOI: 10.1126/science.3685967


The distribution of presynaptic endings on the surfaces of autonomic ganglion cells was mapped in living mice after intravenous administration of a styryl pyridinium dye. The staining and imaging techniques did not appear to damage the ganglion cells, or the synapses on them; these procedures could therefore be repeated after an arbitrary period. Observations of the same neurons at intervals of up to 3 weeks indicate that the pattern of preganglionic terminals on many of these nerve cells gradually changes.