Three-dimensional structure of interleukin-2

See allHide authors and affiliations

Science  18 Dec 1987:
Vol. 238, Issue 4834, pp. 1707-1709
DOI: 10.1126/science.3500515


Interleukin-2 is an effector protein that participates in modulating the immune response; it has become a focal point for the study of lymphokine structure and function. The three-dimensional structure of the interleukin molecule has been solved to 3.0 angstrom resolution. Interleukin-2 has a novel alpha-helical tertiary structure that suggests one portion of the molecule forms a structural scaffold, which underlies the receptor binding facets of the molecule.