Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis

Science  01 Jan 1988:
Vol. 239, Issue 4835, pp. 55-57
DOI: 10.1126/science.3336774


Although periodontitis is a bacterial disease, its multidimensional nature and its bacterial complexity have made it difficult to definitively prove that specific microorganisms initiate the disease process. The successful implantation of a rifampin-resistant strain of the putative periodontal pathogen Bacteroides gingivalis into the periodontal microbiota of monkeys (Macaca fascicularis) resulted in an increase in the systemic levels of antibody to the microorganism and rapid and significant bone loss.

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