One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes

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Science  12 Feb 1988:
Vol. 239, Issue 4841, pp. 786-788
DOI: 10.1126/science.3257586


Four different regulatory sites required for transcriptional stimulation by the enhancers of two unrelated liver-specific genes alpha 1-antitrypsin and transthyretin appear to bind the same nuclear protein that is found mainly in the liver. Such proteins may provide a basis for a coordinated, hepatocyte-specific control of gene transcription.