Research Articles

Purification and characterization of mouse hematopoietic stem cells

Science  01 Jul 1988:
Vol. 241, Issue 4861, pp. 58-62
DOI: 10.1126/science.2898810

Abstract

Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.

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