Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells

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Science  19 Aug 1988:
Vol. 241, Issue 4868, pp. 968-970
DOI: 10.1126/science.2457254


A tenfold increase in phospholipase C activity specific for phosphatidylinositol 4,5-bisphosphate (PIP2) was immunopurified from extracts of A-431 epidermoid carcinoma cells stimulated with epidermal growth factor. This finding suggests a biochemical link between growth factor-stimulated tyrosine kinase activity and PIP2 hydrolysis.

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