Mitotic recombination within the centromere of a yeast chromosome

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Science  26 Aug 1988:
Vol. 241, Issue 4869, pp. 1074-1077
DOI: 10.1126/science.3137657


Centromeres are the structural elements of eukaryotic chromosomes that hold sister chromatids together and to which spindle tubules connect during cell division. Centromeres have been shown to suppress meiotic recombination in some systems. In this study yeast strains genetically marked within and flanking a centromere, were used to demonstrate that gene conversion (nonreciprocal recombination) tracts in mitosis can enter into and extend through the centromere.