Recognition and transport of adenine derivatives with synthetic receptors

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Science  14 Oct 1988:
Vol. 242, Issue 4876, pp. 266-268
DOI: 10.1126/science.3262924


Several new synthetic agents show high affinity for binding adenine derivatives. The structures feature complementary hydrogen bonds that cause the molecular chelation of the purine nucleus. The high lipophilicity of the new agents permits the transport of adenosine and deoxyadenosine across organic liquid membranes. The use of synthetic receptors for small biological targets may have application in drug delivery.