A 115-kD polypeptide immunologically related to erythrocyte band 3 is present in Golgi membranes

See allHide authors and affiliations

Science  02 Dec 1988:
Vol. 242, Issue 4883, pp. 1308-1311
DOI: 10.1126/science.2461589


Band 3 multigene family consists of several distinct but structurally related polypeptides which are probably involved in the transport of anions across the plasma membrane of both erythrocytes and nonerythroid cells. A novel member of this family of polypeptides that resides in the Golgi complex was identified with antibodies to Band 3. The Golgi antigen had a larger molecular size and was antigenically distinct from Band 3 in the amino-terminal domain. It was expressed most prominently in cells that secrete large amounts of sulfated proteins and proteoglycans. This polypeptide may participate in sulfate transport across Golgi membranes.