Articles

Innovative approaches to plasminogen activator therapy

See allHide authors and affiliations

Science  06 Jan 1989:
Vol. 243, Issue 4887, pp. 51-56
DOI: 10.1126/science.2492113

Abstract

Plasminogen activator therapy for acute myocardial infarction has become standard medical practice. Bleeding complications, however, limit the utility of the currently available agents. This article reviews how the tools of molecular biology and protein engineering are being used to develop safer and more effective plasminogen activators.