Reports

Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II

Science  06 Jan 1989:
Vol. 243, Issue 4887, pp. 83-85
DOI: 10.1126/science.2911721

Abstract

Antigen (egg albumin) injections, which stimulate mucosal mast cells to secrete mediators, were paired with an audiovisual cue. After reexposure to the audiovisual cue, a mediator (rat mast cell protease II) was measured with a sensitive and specific assay. Animals reexposed to only the audiovisual cue released a quantity of protease not significantly different from animals reexposed to both the cue and the antigen; these groups released significantly more protease than animals that had received the cue and antigen in a noncontingent manner. The results support a role for the central nervous system as a functional effector of mast cell function in the allergic state.

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