Research Articles

Molecular sorting in the secretory pathway

Science  13 Jan 1989:
Vol. 243, Issue 4888, pp. 192-197
DOI: 10.1126/science.2911732


Proteins can be secreted from animal cells by either a constitutive or a regulated pathway; those destined for regulated secretion are actively sorted into dense-core secretory granules. Although sorting is generally assumed to be accomplished by specific carriers, the nature of these carriers remains elusive. In this study, peptide hormones were used as affinity ligands to purify a set of 25-kilodalton proteins from canine pancreatic tissue. Their ligand specificities and patterns of expression have the characteristics of sorting carriers.

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